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Architecture for Directed Transport of Superparamagnetic Microbeads in a Magnetic Domain Wall Routing Network

机译:磁畴壁布线网络中超顺磁微珠定向传输的体系结构

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摘要

Directed transport of biological species across the surface of a substrate is essential for realizing lab-on-chip technologies. Approaches that utilize localized magnetic fields to manipulate magnetic particles carrying biological entities are attractive owing to their sensitivity, selectivity, and minimally disruptive impact on biomaterials. Magnetic domain walls in magnetic tracks produce strong localized fields and can be used to capture, transport, and detect individual superparamagnetic microbeads. The dynamics of magnetic microbead transport by domain walls has been well studied. However, demonstration of more complex functions such as selective motion and sorting using continuously driven domain walls in contiguous magnetic tracks is lacking. Here, a junction architecture is introduced that allows for branching networks in which superparamagnetic microbeads can be routed along dynamically-selected paths by a combination of rotating in-plane field for translation, and a pulsed out-of-plane field for path selection. Moreover, experiments and modeling show that the select-field amplitude is bead-size dependent, which allows for digital sorting of multiple bead populations using automated field sequences. This work provides a simple means to implement complex routing networks and selective transport functionalities in chip-based devices using magnetic domain wall conduits.
机译:生物物种在基板表面上的直接运输对于实现芯片实验室技术至关重要。利用局部磁场来操纵携带生物实体的磁性粒子的方法具有吸引力,因为它们具有灵敏性,选择性和对生物材料的最小破坏性影响。磁道中的磁畴壁会产生很强的局部磁场,可用于捕获,运输和检测单个超顺磁微珠。磁微珠通过畴壁传输的动力学已得到很好的研究。但是,缺乏在连续磁道中使用连续驱动的畴壁进行更复杂功能(例如选择性运动和分类)的演示。在这里,引入了一种结点体系结构,该结点体系结构允许分支网络,其中超顺磁性微珠可以通过旋转的平面内场进行平移和脉冲的平面外场进行路径选择的组合沿动态选择的路径进行布线。此外,实验和建模表明,选择场的幅度取决于珠子的大小,这允许使用自动场序列对多个珠子种群进行数字排序。这项工作为使用磁畴壁导管在基于芯片的设备中实现复杂的路由网络和选择性传输功能提供了一种简单的方法。

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